Searchable abstracts of presentations at key conferences in endocrinology

ea0063p214 | Diabetes, Obesity and Metabolism 1 | ECE2019

Peroxisome proliferator activated receptor gamma mutation responsible for partial lipodystrophy with end stage renal disease: pharmacokinetics of metreleptine during hemodialysis: Clinical case report

Archambeaud Francoise , Vital Pauline , Galinat Sophie , Drutel Anne , Plas Camille , Vantyghem Marie Christine , Vigouroux Corinne

Lipodystrophy is a rare disorder characterised by loss of adipose tissue, severe insulin resistance, diabetes, hypertriglyceridemia, hepatic steatosis with hypoleptinemia. Renal complications are also present but end stage renal disease is less frequent in partial lipodystrophy. We report efficacy and pharmacokinetics of metreleptine during hemodialysis in one case of partial lipodystrophy. A caucasian female presented with acute pancreatitis, major hypertriglyceridemia (25 g/...